This article investigates uptake of prevention of MTCT (PMTCT) services, infant feeding recommendations, and specific drug regimens necessary to achieve the virtual elimination of pediatric HIV in Zimbabwe. The authors used a computer model to simulate a cohort of HIV-infected, pregnant/breastfeeding women, and evaluated three PMTCT regiments: single-dose
nevirapine (sdNVP); WHO 2010 guidelines’ ‘‘Option A’’ (zidovudine in pregnancy, infant nevirapine throughout breastfeeding for women without advanced disease, lifelong combination antiretroviral therapy for women with advanced disease); and WHO ‘‘Option B’’ (pregnancy/breastfeeding-limited combination antiretroviral drug regimens without advanced disease; lifelong antiretroviral therapy with advanced disease). They found that the latest WHO PMTCT guidelines plus better access to PMTCT programmes, better retention of women in care, and better adherence to drugs are needed to eliminate pediatric HIV in Zimbabwe.