These guidelines are designed to provide basic and flexible guidance on how to (i) conduct impact and vulnerability assessments in the health sector; (ii) identify opportunities and entry points for integration of climate change mitigation and adaptation (CCMA) measures; iii) identify, analyse and integrate options for CCMA into the health policy formulation, financing, implementation and evaluation at national, local and community levels. The guidelines will assist to improve the resilience of Rwanda’s health care delivery system to climate change effects.